Corona: Hepatitis in children – Corona virus can be the trigger


Hepatitis in children: Corona may be the trigger

The diseases hepatitis

The diseases hepatitis

Hepatitis virus is dangerous. The video explains how and when a disease affects itself after infection.

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Does the accumulation of hepatitis in children have anything to do with Corona? A new study supports this dissertation. But she is being criticized.

Berlin. A new study from Israel claims to have found evidence that the unusual accumulation of Cases of hepatitis in children, which has attracted international attention for weeks, can be related to Corona. Inflammation can be a long-term side effect of a Sars-CoV-2 infection. German scientists consider the conclusions premature.

According to the European Center for Disease Prevention and Control (ECDC), there are per. June 9 reported over 400 cases of acute hepatitis of unknown origin in children up to 16 years from the European region. WHO is talking about about 700 cases worldwide. An association with a Covid-19 disease alone or in combination with other viral infections, primarily caused by adenoviruses, has been discussed for weeks.

In a small case study published in the Journal of Pediatric Gastroenterology and Nutrition, Israeli researchers now describe five cases of damage to the liver and bile ducts in children, all of whom have previously been shown to have a Covid 19 infection. All had an asymptomatic or mild course.

Hepatitis in children: Evidence of immune overreaction and inflammation

One appeared out of two healthy infants aged three and five months liver failure, which quickly led to a liver transplant. The other three children aged eight and 13 had hepatitis with bile stasis. According to the study, investigations into other infectious causes of liver damage failed. However, much indicated a strong immune response and persistent inflammation.

The researchers talk about “Long Covid-19 liver manifestation” in the title of their study. In addition, they formulate the thesis that liver or gallbladder injuries can be a rare occurrence long-term side effect of CovidD-19 infection in children.

Out of a total of 273 cases of hepatitis in children in the EU diagnosed using PCR test According to the ECDC, only 29 (10.6 percent) were positive for Sars-CoV-2. However, indications of previous infections based on blood values ​​were only available for 47 cases, of which 30 (63.8) had a positive result. Of the 94 cases with information about the Covid 19 vaccination, more than 85 percent were not vaccinated.

Doctors from Germany: “Relationship remains speculative”

Doctors and virologists from Germany consider the conclusions of their colleagues from Israel to be premature: “The individual cases described in this study show a certain temporal connection, which is so different from case to case that there is a causal connection. speculative remains, ”says Prof. Ansgar Lohse, director of the medical clinic and outpatient clinic at the University Hospital Hamburg-Eppendorf.

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Overall, the individual cases are described and processed insufficient, says Prof. Sandra Ciesek, Director of the Department of Medical Virology at the University Hospital in Frankfurt. They are too different. “The deterogenicity of the cases is reflected not only in the age of the patients, but also in the clinical course. While the two younger children had to have a liver transplant, the three older children were treated with steroids, “says Ciesek.

The older kids are too time courses extremely varied. “While a child first developed obscure hepatitis more than four months after the Sars-CoV-2 infection, the 13-year-old developed hepatitis at the time of the infection itself. The possible pathomechanisms in these cases are therefore also very different.”

Virologist Ciesek calls for further treatment of hepatitis cases

Also the extended one virological testing was inconsistent in the cases and in some cases incomplete. “For example, an acute hepatitis E virus infection was not ruled out in any of the children,” Ciesek continues. Although the study contains some important general considerations about a possible link between hepatitis and Covid-19, it does not help to find the cause. The proposed link between a Sars-CoV-2 infection in children and severe liver damage, on the other hand, can trigger unfounded fears.

So for Ciesek causal analysis not finished. “Concrete recommendations cannot be deduced from the five cases. In summary, the currently reported cases of severe acute hepatitis in children should be carefully treated medically. Ciesek: “Involvement of Sars-CoV-2 is still neither proven nor ruled out.” (kai)

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